Brian E Cairns Selected Research

Intramuscular Injections

1/2021	Nerve growth factor and glutamate increase the density and expression of substance P-containing nerve fibers in healthy human masseter muscles.
12/2019	The pro-algesic effect of γ-aminobutyric acid (GABA) injection into the masseter muscle of healthy men and women.
4/2012	Comparison of glutamate-evoked pain between the temporalis and masseter muscles in men and women.
12/2010	Botulinum neurotoxin type A (BoNTA) decreases the mechanical sensitivity of nociceptors and inhibits neurogenic vasodilation in a craniofacial muscle targeted for migraine prophylaxis.
1/2008	Effect of peripheral NMDA receptor blockade with ketamine on chronic myofascial pain in temporomandibular disorder patients: a randomized, double-blinded, placebo-controlled trial.
2/2003	Activation of peripheral excitatory amino acid receptors decreases the duration of local anesthesia.

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Brian E Cairns Research Topics

Disease

36	Pain (Aches) 03/2022 - 01/2003
15	Myalgia 12/2019 - 10/2003
10	Temporomandibular Joint Disorders (Temporomandibular Joint Disorder) 01/2021 - 01/2005
7	Migraine Disorders (Migraine) 10/2021 - 12/2010
7	Hyperalgesia 01/2021 - 02/2003
4	Inflammation (Inflammations) 01/2017 - 01/2005
3	Headache (Headaches) 01/2022 - 01/2013
3	Ganglion Cysts (Ganglion) 01/2021 - 01/2012
3	Fibromyalgia (Fibrositis) 08/2019 - 01/2005
3	Facial Pain (Myofacial Pain) 01/2014 - 01/2005
3	Musculoskeletal Pain 12/2009 - 11/2007
2	Neurogenic Inflammation 10/2021 - 02/2014
1	Nausea 01/2022
1	Ischemia 01/2020
1	Chronic Pain 01/2015
1	Neuroinflammatory Diseases 01/2015
1	Burning Mouth Syndrome (Syndrome, Burning Mouth) 03/2014
1	Paralysis (Palsy) 12/2010
1	Referred Pain 01/2006
1	Hypotension (Low Blood Pressure) 12/2004
1	Nociceptive Pain 10/2003
1	Neuralgia (Stump Neuralgia) 07/2003
1	Fever (Fevers) 07/2003
1	Wounds and Injuries (Trauma) 02/2003

Drug/Important Bio-Agent (IBA)

22	Glutamic Acid (Glutamate)FDA Link 10/2021 - 01/2003
8	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2021 - 10/2003
7	Analgesics (Analgesic Drugs)IBA 12/2019 - 10/2003
6	Nerve Growth Factor (NGF)IBA 01/2021 - 07/2003
6	Ketamine FDA LinkGeneric 04/2012 - 02/2003
5	N-Methylaspartate (NMDA)IBA 04/2012 - 10/2003
3	Sodium Glutamate (Accent)IBA 01/2022 - 01/2013
3	Glutamate Receptors (Glutamate Receptor)IBA 10/2021 - 02/2003
3	Type A Botulinum Toxins (Botox)FDA Link 02/2014 - 12/2010
2	CannabinoidsIBA 03/2022 - 08/2019
2	Sumatriptan (Imigran)FDA LinkGeneric 01/2022 - 10/2013
2	Pharmaceutical PreparationsIBA 10/2021 - 01/2008
2	GABA Receptors (GABA Receptor)IBA 01/2021 - 03/2014
2	gamma-Aminobutyric Acid (GABA)IBA 01/2021 - 12/2019
2	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2020 - 08/2009
2	SolutionsIBA 10/2017 - 01/2015
2	Opioid Analgesics (Opioids)IBA 01/2015 - 01/2014
2	Diclofenac (SR 38)FDA LinkGeneric 12/2009 - 02/2008
2	Nerve Growth Factors (Neurotrophins)IBA 07/2008 - 07/2003
1	Naproxen (Naprosyn)FDA LinkGeneric 01/2022
1	NeuropeptidesIBA 10/2021
1	Calcitonin Gene-Related PeptideIBA 10/2021
1	ElementsIBA 10/2021
1	GABA Agonists (GABA Receptor Agonists)IBA 01/2021
1	Substance PIBA 01/2021
1	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 01/2020
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2020
1	Lorazepam (Ativan)FDA LinkGeneric 12/2019
1	CannabinolIBA 08/2019
1	CannabidiolIBA 08/2019
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2019
1	AcidsIBA 10/2017
1	CX3C Chemokine Receptor 1IBA 01/2017
1	Freund's AdjuvantIBA 01/2017
1	Chemokine CX3CL1IBA 01/2017
1	AntibodiesIBA 01/2017
1	p38 Mitogen-Activated Protein KinasesIBA 01/2015
1	CytokinesIBA 01/2015
1	Biomarkers (Surrogate Marker)IBA 09/2014
1	Pain-FreeIBA 09/2014
1	Sodium Channels (Sodium Channel)IBA 09/2014
1	GABA-A Receptors (GABA(A) Receptor)IBA 03/2014
1	BenzodiazepinesIBA 03/2014
1	Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA 10/2013
1	Vasoactive Intestinal Peptide (VIP (Vasoactive Intestinal Peptide))IBA 10/2013
1	Propranolol (Inderal)FDA LinkGeneric 01/2013
1	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2013
1	ORALIT (ORS)IBA 01/2012
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 01/2012
1	Pancuronium (Pavulon)FDA LinkGeneric 12/2010
1	KetorolacIBA 01/2010
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2009
1	Hormones (Hormone)IBA 08/2009
1	Estrogens (Estrogen)FDA Link 08/2009
1	Testosterone (Sustanon)FDA Link 08/2009
1	Adenosine Triphosphate (ATP)IBA 02/2008
1	Local AnestheticsIBA 02/2008
1	Serotonin (5 Hydroxytryptamine)IBA 01/2008
1	Oral ContraceptivesIBA 01/2007
1	P297 (P 297)IBA 01/2005
1	Ionotropic Glutamate ReceptorsIBA 01/2005
1	Tetrodotoxin (Tetradotoxin)IBA 12/2004
1	Excitatory Amino Acid AgonistsIBA 10/2003
1	Kynurenic Acid (Kynurenate)IBA 02/2003
1	Bupivacaine (Bupivacaine Hydrochloride)FDA LinkGeneric 02/2003
1	Lidocaine (Xylocaine)FDA LinkGeneric 02/2003
1	Excitatory Amino AcidsIBA 02/2003
1	D-Aspartic Acid (D Aspartate)IBA 02/2003

Therapy/Procedure

8	Injections 12/2019 - 02/2003
6	Intramuscular Injections 01/2021 - 02/2003
2	Pain Management 01/2015 - 08/2009
2	Bite Force (Occlusal Forces) 01/2010 - 01/2008
1	Drug Therapy (Chemotherapy) 01/2020
1	Electroacupuncture 01/2019
1	Subcutaneous Injections 10/2006
1	Local Anesthesia 02/2003